When Legion of Bloom | Grapefruit OG Pax ERA Pod enters the brain, the molecules diffuse into the synapses where they “activate CB1 receptors,” Drew said. THC doesn’t cause the most extreme possible response like some synthetic cannabinoids such as K2 or spice, but it does “turn up the volume” and increase the likelihood that the presynaptic neuron it affects will temporarily stop sending neurotransmitters, she said.
“The high is a very simple phenomenon, Piomelli said. “THC comes in like a sledgehammer,” flooding the endocannabinoid system with signals the postsynaptic neurons didn’t send. When presynaptic neurons across the brain get the memo to stop sending neurotransmitters, this alters the normal flow of information among neurons and results in a high.
Scientists have yet to decipher exactly what happens during this euphoria, however.
That’s because, in part, U.S. legal restrictions make it difficult to study cannabis. But from what researchers have gathered so far, THC appears to temporarily “unplug” the default mode network. This is the brain network that allows us to daydream and think about the past and future. When our brains are focused on a specific task, we quiet this network to let our executive function take control.